Intraosseous malignant peripheral nerve sheath tumor with focal epithelioid differentiation of the thoracic spine

Naohisa Miyakoshi, Yuji Nishikawa, Yoichi Shimada, Kyoji Okada, Masayuki Yoshida, Katsuhiko Enomoto, Eiji Itoi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The authors describe an extremely rare case with malignant peripheral nerve sheath tumor (MPNST) with focal epithelioid differentiation presenting as an intraosseous lesion of the spine. A 75-year-old woman presented with progressive paraplegia caused by epidural mass arising from the posterior element of the T7 vertebra. At surgery, the lesion was noted to originate from the T7 vertebra and separate from the dura and spinal nerve roots. The patient died of tumor metastases to the lungs six months after the initial presentation. Histological diagnosis was MPNST. However, the tumor also contained cystic structures lined by epithelioid cells, requiring differentiation from synovial sarcoma. From the histological and immunohistochemical features, as well as the absence of SYT-SSX fusion gene expression, the diagnosis of MPNST with focal epithelioid differentiation was made. This is the first case report of intraosseous MPNST of the spine with a peculiar biphasic appearance.

Original languageEnglish
Pages (from-to)64-66
Number of pages3
JournalNeurology India
Volume55
Issue number1
DOIs
Publication statusPublished - 2007 Jan 1
Externally publishedYes

Keywords

  • Epithelioid differentiation
  • Intraosseous tumor
  • Malignant peripheral nerve sheath tumor
  • Spine

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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