Intramolecular nucleophilic aromatic substitution reaction of 2-carboxamido-3-arylquinazolin-4-ones and its application to the synthesis of secondary aryl amines

Haruhiko Fuwa, Toshitake Kobayashi, Takashi Tokitoh, Yukiko Torii, Hideaki Natsugari

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    A novel intramolecular nucleophilic aromatic substitution reaction of 2-carboxamido-3-arylquinazolin-4-one derivatives induced by base treatment and its application to the expeditious synthesis of secondary aryl amines, including diaryl amines, are described.

    Original languageEnglish
    Pages (from-to)2497-2500
    Number of pages4
    JournalSynlett
    Issue number14
    DOIs
    Publication statusPublished - 2004 Nov 22

    Keywords

    • Amines
    • Heterocycles
    • Medicinal chemistry
    • Nucleophilic aromatic substitutions
    • Tandem reactions

    ASJC Scopus subject areas

    • Organic Chemistry

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