Intramolecular 1,3-dipolar cycloaddition strategy for enantioselective synthesis of FR-900482 analogues

Mika Kambe; Eri Arai; Masashi Suzuki; Hidetoshi Tokuyama; Tohru Fukuyama

doi:10.1021/ol016243t

Intramolecular 1,3-dipolar cycloaddition strategy for enantioselective synthesis of FR-900482 analogues

Mika Kambe, Eri Arai, Masashi Suzuki, Hidetoshi Tokuyama, Tohru Fukuyama

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

(Equation presented) Enantioselective synthesis of FR-900482 analogues is described. The key reaction of the synthesis is intramolecular 1,3-dipolar cycloaddition of a highly functionalized nitrile oxide with complete stereo-and regioselectivities to construct the eight-membered benzazocine ring.

Original language	English
Pages (from-to)	2575-2578
Number of pages	4
Journal	Organic letters
Volume	3
Issue number	16
DOIs	https://doi.org/10.1021/ol016243t
Publication status	Published - 2001 Aug 9
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol016243t

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title = "Intramolecular 1,3-dipolar cycloaddition strategy for enantioselective synthesis of FR-900482 analogues",

abstract = "(Equation presented) Enantioselective synthesis of FR-900482 analogues is described. The key reaction of the synthesis is intramolecular 1,3-dipolar cycloaddition of a highly functionalized nitrile oxide with complete stereo-and regioselectivities to construct the eight-membered benzazocine ring.",

author = "Mika Kambe and Eri Arai and Masashi Suzuki and Hidetoshi Tokuyama and Tohru Fukuyama",

year = "2001",

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doi = "10.1021/ol016243t",

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T1 - Intramolecular 1,3-dipolar cycloaddition strategy for enantioselective synthesis of FR-900482 analogues

AU - Kambe, Mika

AU - Arai, Eri

AU - Suzuki, Masashi

AU - Tokuyama, Hidetoshi

AU - Fukuyama, Tohru

PY - 2001/8/9

Y1 - 2001/8/9

N2 - (Equation presented) Enantioselective synthesis of FR-900482 analogues is described. The key reaction of the synthesis is intramolecular 1,3-dipolar cycloaddition of a highly functionalized nitrile oxide with complete stereo-and regioselectivities to construct the eight-membered benzazocine ring.

AB - (Equation presented) Enantioselective synthesis of FR-900482 analogues is described. The key reaction of the synthesis is intramolecular 1,3-dipolar cycloaddition of a highly functionalized nitrile oxide with complete stereo-and regioselectivities to construct the eight-membered benzazocine ring.

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M3 - Article

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JO - Organic Letters

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ER -

Intramolecular 1,3-dipolar cycloaddition strategy for enantioselective synthesis of FR-900482 analogues

Abstract

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