Intramolecular 1,3-dipolar cycloaddition strategy for enantioselective synthesis of FR-900482 analogues

Mika Kambe, Eri Arai, Masashi Suzuki, Hidetoshi Tokuyama, Tohru Fukuyama

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

(Equation presented) Enantioselective synthesis of FR-900482 analogues is described. The key reaction of the synthesis is intramolecular 1,3-dipolar cycloaddition of a highly functionalized nitrile oxide with complete stereo-and regioselectivities to construct the eight-membered benzazocine ring.

Original languageEnglish
Pages (from-to)2575-2578
Number of pages4
JournalOrganic letters
Volume3
Issue number16
DOIs
Publication statusPublished - 2001 Aug 9
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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