Intragenic haplotypes and molecular evolution of the human α2-HS glycoprotein (AHSG/fetuin) gene

M. Osawa, I. Yuasa, J. Henke, M. Kaneko, K. Umetsu

Research output: Contribution to journalArticle

Abstract

α2-HS glycoprotein (AHSG/fetuin) is a human plasma protein that is polymorphic with two common alleles and many variants. To investigate molecular evolution at this locus, intragenic haplotypes was analyzed by a contiguous genomic sequencing, and their frequencies were determined for 309 subjects. Judging from the aligned nucleotide sequences in the human and chimpanzee genes, it was concluded that the type 1 allele is older and has evolved into four major suballeles. The type 2 allele was generated from one major branch of the type 1 allele. The AHSG gene had a low mutation rate and nonhomogeneous distribution of the substitutions.

Original languageEnglish
Pages (from-to)765-767
Number of pages3
JournalInternational Congress Series
Volume1239
Issue numberC
DOIs
Publication statusPublished - 2003 Jan 1
Externally publishedYes

Keywords

  • Molecular evolution
  • α2-HS glycoprotein

ASJC Scopus subject areas

  • Medicine(all)

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