Intraduodenal capsaicin inhibits gastric migrating motor complex via an extrinsic neural reflex in conscious dogs

C. Shibata, H. Naito, T. Ueno, X. L. Jin, Y. Funayama, K. Fukushima, S. Matsuno, I. Sasaki

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

The aim was to study the effect of intraduodenal capsaicin on interdigestive gastric contractions. Mongrel dogs were equipped with strain-gauge force transducers to measure gastroduodenal motility. The effects of intraduodenal capsaicin with or without pharmacological antagonists on spontaneous and motilin-induced interdigestive gastric contractions and on plasma motilin were studied in dogs with intact stomachs. The effect of intraduodenal capsaicin on gastric contractions was also studied in vagally denervated gastric (Heidenhain) pouch and vagally innervated antral pouch. Intraduodenal capsaicin inhibited spontaneous and motilin-induced gastric contractions. The spontaneous peak in plasma motilin was inhibited by intraduodenal capsaicin. The effect of intraduodenal capsaicin on motilin-induced gastric contractions was not affected by blockade of nitric oxide synthase, or by β-adrenoceptor antagonist. Administration of α-adrenergic blocker inhibited basal interdigestive gastric motility. Intraduodenal capsaicin had no effect on contractions in the Heidenhain pouch but inhibited those in vagally innervated antral pouch. Duodenal afferent fibres stimulated by capsaicin inhibit gastric contractions via a nitric oxide-independent extrinsic neural reflex.

Original languageEnglish
Pages (from-to)543-551
Number of pages9
JournalNeurogastroenterology and Motility
Volume14
Issue number5
DOIs
Publication statusPublished - 2002

Keywords

  • Adrenoceptor
  • Afferent fibres
  • Motilin
  • Nitric oxide
  • Vagal nerve

ASJC Scopus subject areas

  • Physiology
  • Endocrine and Autonomic Systems
  • Gastroenterology

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