TY - JOUR
T1 - Intradermal measurement of reactive oxygen species using open-tip porous microneedles
AU - Abe, Yuina
AU - Yamaguchi, Shuhei
AU - Abe, Hiroya
AU - Takizawa, Ryohei
AU - Tatsui, Yuki
AU - Nishizawa, Matsuhiko
N1 - Funding Information:
This work was financially supported by Tohoku University Frontier Research program (FRiD), Grant-in-Aids for Research Activity Start-up [grant number 20K22490 ], Scientific Research A [grant number 18H04158 ], Early-Career Scientists [grant number 19K15598 ], and Challenging Exploratory Research [grant number 20K21877 ] from the Ministry of Education, Culture, Sports, Science and Technology , Japan.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/9/15
Y1 - 2022/9/15
N2 - Reactive oxygen species (ROS), which constitute a representative group of substances associated with skin health, are promising indicators of oxidative stress. A local electrochemical system can measure ROS with minimal invasiveness. In this study, a microneedle-based amperometric sensor is developed for real-time monitoring of changes in the H2O2 concentration of the skin. Two electrodes can be mounted on a single open-tip porous microneedle (PMN), which allows local measurement without intradermal noise caused by the high resistance and non-uniform distribution of the potential difference. The PMN electrode shows a current response in accordance with the H2O2 concentration, and amperometric measurement of ex vivo skin samples is successfully performed. The results indicate that a compact system based on a single needle is a promising tool for intracutaneous sensing of biological signals.
AB - Reactive oxygen species (ROS), which constitute a representative group of substances associated with skin health, are promising indicators of oxidative stress. A local electrochemical system can measure ROS with minimal invasiveness. In this study, a microneedle-based amperometric sensor is developed for real-time monitoring of changes in the H2O2 concentration of the skin. Two electrodes can be mounted on a single open-tip porous microneedle (PMN), which allows local measurement without intradermal noise caused by the high resistance and non-uniform distribution of the potential difference. The PMN electrode shows a current response in accordance with the H2O2 concentration, and amperometric measurement of ex vivo skin samples is successfully performed. The results indicate that a compact system based on a single needle is a promising tool for intracutaneous sensing of biological signals.
KW - Biosensing
KW - Electrochemical sensor
KW - Microelectrode
KW - Microneedle
KW - Reactive oxygen species (ROS)
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U2 - 10.1016/j.mee.2022.111877
DO - 10.1016/j.mee.2022.111877
M3 - Article
AN - SCOPUS:85138021066
SN - 0167-9317
VL - 265
JO - Microelectronic Engineering
JF - Microelectronic Engineering
M1 - 111877
ER -