Intracytoplasmic sperm injection: Stiletto conception or a stab in the dark

Y. Terada, S. Nakamura, J. Morita, C. Simerly, L. Hewitson, T. Murakami, N. Yaegashi, G. Schatten, K. Okamura

Research output: Contribution to journalReview articlepeer-review

7 Citations (Scopus)


To describe the importance of molecular and cellular analyses in intracytoplasmic sperm injection (ICSI) the authors review the literature on biological challenges in ICSI and associated techniques. Several matters can be proposed in molecular and cellular challenges in ICSI for safety and efficacy: (1) a reliable and convenient animal model for understanding the molecular and cellular basis of human ICSI must be established, and molecular and cellular analysis of the first cell cycle of human fertilization should be better understood; (2) a proper assay for human sperm function that contributes to the indication for ICSI should be developed; and (3) de novo and transmitted genetic security in ICSI should be examined.

Original languageEnglish
Pages (from-to)169-177
Number of pages9
JournalArchives of Andrology
Issue number3
Publication statusPublished - 2003

ASJC Scopus subject areas

  • Endocrinology


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