Intractable bleeding tendency due to acquired von Willebrand syndrome after Jarvik 2000 implant

Ko Sakatsume, Masatoshi Akiyama, Kenki Saito, Shunsuke Kawamoto, Hisanori Horiuchi, Yoshikatsu Saiki

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


A 61-year-old man was implanted with a Jarvik 2000, a continuous axial flow type left ventricular assist device (LVAD), for end-stage heart failure due to dilated cardiomyopathy. One month later, his postoperative course was complicated with intractable oozing-type gastrointestinal bleeding from multiple small shallow ulcers and erosions in the colon. In addition, repeated bleeding episodes were encountered at around thoracentesis site for pleural effusion. Hematological examination showed that platelet counts and coagulation factors were kept within normal ranges. We, thereafter, revealed remarkable loss of the large multimers of von Willebrand factors (VWFs), which might be closely associated with his intractable bleeding tendency.

Original languageEnglish
Pages (from-to)289-292
Number of pages4
JournalJournal of Artificial Organs
Issue number3
Publication statusPublished - 2016 Sep 1


  • Acquired von Willebrand syndrome
  • Bleeding tendency
  • Ventricular assist device
  • Von Willebrand factors

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering
  • Cardiology and Cardiovascular Medicine


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