Intractable bleeding tendency due to acquired von Willebrand syndrome after Jarvik 2000 implant

Ko Sakatsume; Masatoshi Akiyama; Kenki Saito; Shunsuke Kawamoto; Hisanori Horiuchi; Yoshikatsu Saiki

doi:10.1007/s10047-016-0896-7

Intractable bleeding tendency due to acquired von Willebrand syndrome after Jarvik 2000 implant

Ko Sakatsume, Masatoshi Akiyama, Kenki Saito, Shunsuke Kawamoto, Hisanori Horiuchi, Yoshikatsu Saiki

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

A 61-year-old man was implanted with a Jarvik 2000, a continuous axial flow type left ventricular assist device (LVAD), for end-stage heart failure due to dilated cardiomyopathy. One month later, his postoperative course was complicated with intractable oozing-type gastrointestinal bleeding from multiple small shallow ulcers and erosions in the colon. In addition, repeated bleeding episodes were encountered at around thoracentesis site for pleural effusion. Hematological examination showed that platelet counts and coagulation factors were kept within normal ranges. We, thereafter, revealed remarkable loss of the large multimers of von Willebrand factors (VWFs), which might be closely associated with his intractable bleeding tendency.

Original language	English
Pages (from-to)	289-292
Number of pages	4
Journal	Journal of Artificial Organs
Volume	19
Issue number	3
DOIs	https://doi.org/10.1007/s10047-016-0896-7
Publication status	Published - 2016 Sep 1

Keywords

Acquired von Willebrand syndrome
Bleeding tendency
Ventricular assist device
Von Willebrand factors

ASJC Scopus subject areas

Medicine (miscellaneous)
Biomaterials
Biomedical Engineering
Cardiology and Cardiovascular Medicine

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10.1007/s10047-016-0896-7

Cite this

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title = "Intractable bleeding tendency due to acquired von Willebrand syndrome after Jarvik 2000 implant",

abstract = "A 61-year-old man was implanted with a Jarvik 2000, a continuous axial flow type left ventricular assist device (LVAD), for end-stage heart failure due to dilated cardiomyopathy. One month later, his postoperative course was complicated with intractable oozing-type gastrointestinal bleeding from multiple small shallow ulcers and erosions in the colon. In addition, repeated bleeding episodes were encountered at around thoracentesis site for pleural effusion. Hematological examination showed that platelet counts and coagulation factors were kept within normal ranges. We, thereafter, revealed remarkable loss of the large multimers of von Willebrand factors (VWFs), which might be closely associated with his intractable bleeding tendency.",

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T1 - Intractable bleeding tendency due to acquired von Willebrand syndrome after Jarvik 2000 implant

AU - Sakatsume, Ko

AU - Akiyama, Masatoshi

AU - Saito, Kenki

AU - Kawamoto, Shunsuke

AU - Horiuchi, Hisanori

AU - Saiki, Yoshikatsu

PY - 2016/9/1

Y1 - 2016/9/1

N2 - A 61-year-old man was implanted with a Jarvik 2000, a continuous axial flow type left ventricular assist device (LVAD), for end-stage heart failure due to dilated cardiomyopathy. One month later, his postoperative course was complicated with intractable oozing-type gastrointestinal bleeding from multiple small shallow ulcers and erosions in the colon. In addition, repeated bleeding episodes were encountered at around thoracentesis site for pleural effusion. Hematological examination showed that platelet counts and coagulation factors were kept within normal ranges. We, thereafter, revealed remarkable loss of the large multimers of von Willebrand factors (VWFs), which might be closely associated with his intractable bleeding tendency.

AB - A 61-year-old man was implanted with a Jarvik 2000, a continuous axial flow type left ventricular assist device (LVAD), for end-stage heart failure due to dilated cardiomyopathy. One month later, his postoperative course was complicated with intractable oozing-type gastrointestinal bleeding from multiple small shallow ulcers and erosions in the colon. In addition, repeated bleeding episodes were encountered at around thoracentesis site for pleural effusion. Hematological examination showed that platelet counts and coagulation factors were kept within normal ranges. We, thereafter, revealed remarkable loss of the large multimers of von Willebrand factors (VWFs), which might be closely associated with his intractable bleeding tendency.

KW - Acquired von Willebrand syndrome

KW - Bleeding tendency

KW - Ventricular assist device

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Intractable bleeding tendency due to acquired von Willebrand syndrome after Jarvik 2000 implant

Abstract

Keywords

ASJC Scopus subject areas

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