Abstract
Intraoperative diagnostic tissue differentiation is expected to be useful clinically. We have fabricated a 3-mm diameter rod-shaped ultrasound (US) probe mounted with a 120-MHz transducer whose lateral resolution is the same as the cellular size of 13 μm. The probe can image a microscopic structure (i.e., the cellular arrangement inside intracorporeal living tissue). We imaged normal kidney tissue of a living mouse and tumor tissue implanted in another mouse kidney. We anesthetized the mice, exteriorized the kidneys, and punctured the kidneys with the probe. Renal corpuscle-like structures were seen in the healthy kidney, but a wavy spindle-like structure was seen in the tumor. The similarity between the ultrasonic images and histological sections taken from the imaged organs demonstrates the possibility of real-time tissue differentiation by ultra-high-frequency US. (C) 2000 World Federation for Ultrasound in Medicine and Biology.
Original language | English |
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Pages (from-to) | 503-507 |
Number of pages | 5 |
Journal | Ultrasound in Medicine and Biology |
Volume | 26 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2000 May 1 |
Keywords
- Cellular arrangement
- Histological sections
- Implanted tumor
- Intracorporeal living tissue
- Intraoperative tissue differentiation
- Lateral resolution
- Mouse kidney
- Rod-shaped ultrasound probe
- Ultra- high-frequency
ASJC Scopus subject areas
- Biophysics
- Radiological and Ultrasound Technology
- Acoustics and Ultrasonics