Intracorporeal imaging and differentiation of living tissue with an ultra-high-frequency ultrasound probe

Koichi Yokosawa, Kazuaki Sasaki, Shinichiro Umemura, Ryuichi Shinomura, Shizuo Ishikawa, Shyuzo Sano, Yukio Ito

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Intraoperative diagnostic tissue differentiation is expected to be useful clinically. We have fabricated a 3-mm diameter rod-shaped ultrasound (US) probe mounted with a 120-MHz transducer whose lateral resolution is the same as the cellular size of 13 μm. The probe can image a microscopic structure (i.e., the cellular arrangement inside intracorporeal living tissue). We imaged normal kidney tissue of a living mouse and tumor tissue implanted in another mouse kidney. We anesthetized the mice, exteriorized the kidneys, and punctured the kidneys with the probe. Renal corpuscle-like structures were seen in the healthy kidney, but a wavy spindle-like structure was seen in the tumor. The similarity between the ultrasonic images and histological sections taken from the imaged organs demonstrates the possibility of real-time tissue differentiation by ultra-high-frequency US. (C) 2000 World Federation for Ultrasound in Medicine and Biology.

Original languageEnglish
Pages (from-to)503-507
Number of pages5
JournalUltrasound in Medicine and Biology
Issue number4
Publication statusPublished - 2000 May 1


  • Cellular arrangement
  • Histological sections
  • Implanted tumor
  • Intracorporeal living tissue
  • Intraoperative tissue differentiation
  • Lateral resolution
  • Mouse kidney
  • Rod-shaped ultrasound probe
  • Ultra- high-frequency

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics


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