Intracholecystic papillary neoplasm arising in the cystic duct and extending into common bile duct: a case report

Masahiro Iseki, Masamichi Mizuma, Yasutaka Aoki, Shuichi Aoki, Tatsuo Hata, Tatsuyuki Takadate, Kei Kawaguchi, Kunihiro Masuda, Masaharu Ishida, Hideo Ohtsuka, Kei Nakagawa, Hiroki Hayashi, Takanori Morikawa, Takashi Kamei, Kiyoshi Kume, Atsushi Kanno, Atsushi Masamune, Yuko Omori, Yusuke Ono, Yusuke MizukamiToru Furukawa, Michiaki Unno

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

An 83-year-old man without specific symptoms was referred to our hospital for further evaluation and treatment of apparent double primary tumors of the cystic duct and common bile duct. Computed tomography showed contrast-enhanced solid tumors in the cystic duct and common bile duct. Magnetic resonance imaging showed that the bile duct tumor was isointense on T1-weighted images and had low intensity on T2-weighted images. In addition, the bile duct tumor showed high intensity on diffusion-weighted images. Endoscopic ultrasonography revealed the tumor of the common bile duct and endoscopic retrograde cholangiopancreatography demonstrated a filling defect in the bile duct. The cystic duct was not identified on endoscopic ultrasonography or endoscopic retrograde cholangiopancreatography. Transpapillary biopsy of the bile duct tumor showed adenocarcinoma. The patient was diagnosed with double primary tumors of the cystic duct and the common bile duct and underwent subtotal stomach-preserving pancreaticoduodenectomy. Microscopic examination with molecular profiling of the tumors revealed a high-grade noninvasive intracholecystic papillary neoplasm of the cystic duct extending into the common bile duct and forming a tubulopapillary neoplasm with invasion of the common bile duct.

Original languageEnglish
Pages (from-to)668-677
Number of pages10
JournalClinical Journal of Gastroenterology
Volume14
Issue number2
DOIs
Publication statusPublished - 2021 Apr
Externally publishedYes

Keywords

  • ICPN (intracholecystic papillary neoplasm)
  • IPNB (intraductal papillary neoplasm of bile duct)
  • Intraepithelial progression
  • Invasion

ASJC Scopus subject areas

  • Gastroenterology

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