Intracellular Magnesium Deficiency in Acute Myocardial Infarction

Masato Tsutsui, Hiroaki Shimokawa, Shingo Yoshihara, Atsushi Sobashima, Kiyoshi Hayashida, Seiji Higuchi, Kunihiko Yamamoto, Takeyuki Matsuguchi, Shuichi Okamatsu

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

It has been hypothesized that intracellular magnesium deficiency is a pathogenetic factor in acute myocardial infarction. This study examined the time course of changes in the erythrocyte magnesium concentration and the correlation between the erythrocyte magnesium concentration and the severity of acute myocardial infarction in 49 consecutive patients with transmural acute myocardial infarction. The data were compared with results from 20 control patients without ischemic heart disease. The erythrocyte magnesium concentration (mg/dl) decreased significantly during the acute phase of the infarction (4.86+0.09 on day 1, 4.89±0.10 on day 2 and 4.86±0.10 on day 3 versus 5.26+0.19 for controls, all p<0.05) and then normalized gradually to 5.25±0.10 on day 28. The serum magnesium concentration (mg/d/) also decreased significantly during the acute phase of the infarction (1.93±0.04 on day 1 and 2.11±0.03 on day 2 versus 2.26±0.08 for controls, all p<0.05), before recovering to 2.28±0.06 on day 28. There were significant correlations between the erythrocyte magnesium concentration on day 1 and maximal values of serum cardiac enzymes (r = - 0.30 for creatine kinase, r = - 0.34 for glutamic oxaloacetic transaminase and r = - 0.57 for lactate dehydrogenase, all p<0.05). Moreover, the erythrocyte magnesium concentration was significantly lower in patients with (4.32±0.08 mg/dl, n=13) than in those without (5.06±0.09 mg/dl, n=36, p<0.0001) serious arrhythmias. These data indicate that intracellular magnesium deficiency is involved in the acute phase of myocardial infarction. (Jpn Heart J 34: 391-401, 1993.).

Original languageEnglish
Pages (from-to)391-401
Number of pages11
JournalJapanese Heart Journal
Volume34
Issue number4
DOIs
Publication statusPublished - 1993

Keywords

  • Arrhythmia
  • Ischemic heart disease
  • Myocardial necrosis
  • Sudden death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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