Intracellular and extracellular ATP coordinately regulate the inverse correlation between osteoclast survival and bone resorption

Tsuyoshi Miyazaki, Mitsuyasu Iwasawa, Tomoki Nakashima, Shuuichi Mori, Kazuhiro Shigemoto, Hiroaki Nakamura, Hideki Katagiri, Hiroshi Takayanagi, Sakae Tanaka

Research output: Contribution to journalArticlepeer-review

67 Citations (Scopus)

Abstract

Background: Mature osteoclasts with a spontaneous tendency toward apoptosis resorb bone efficiently during their short lifespan. Results: Released ATP from intracellular stores has a negative impact on the bone resorption activity of osteoclasts by altering their cytoskeletal structures. Conclusion: ATP depletion leads to osteoclastic bone resorption. Significance: This study provides a new direction for investigating the mechanisms involved in physiological and pathological bone resorption.

Original languageEnglish
Pages (from-to)37808-37823
Number of pages16
JournalJournal of Biological Chemistry
Volume287
Issue number45
DOIs
Publication statusPublished - 2012 Nov 2
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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