Intraarterial chemotherapy for metastatic renal cell carcinomas: Combination with MDR-overcoming agents

Y. Kakehi, O. Yoshida, T. Segawa, A. Kanematsu, M. Hiura, Y. Shichiri, Y. Arai

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We analyzed the sensitizing activity of five agents, which have been assumed to be MDR-overcoming drugs, in two human renal cell carcinoma cell lines expressing the MDR1 gene at high levels. In addition, we studied the sensitizing activity of cepharanthin, an MDR-overcoming agents, to vinblastine, adriamycin, epirubicin, cisplatin, mitomycin C and etoposide. Based on the results, we treated 6 patients with metastatic renal cell carcinomas (4: bones, 2: contralateral kidneys) by intraarterial injection of vinblastine and adriamycin (or epirubicin) in combination with cepharanthin. Two of the 4 bone metastasis cases responded markedly to the treatment. Renal tubular impairment was observed in one patient who was treated for the contralateral kidney metastasis.

Original languageEnglish
Pages (from-to)925-929
Number of pages5
JournalActa Urologica Japonica
Volume40
Issue number10
Publication statusPublished - 1994 Jan 1

Keywords

  • MDR-overcoming agents
  • intraarterial chemotherapy
  • metastasis
  • renal cell carcinoma

ASJC Scopus subject areas

  • Urology

Fingerprint

Dive into the research topics of 'Intraarterial chemotherapy for metastatic renal cell carcinomas: Combination with MDR-overcoming agents'. Together they form a unique fingerprint.

Cite this