Interrelated effects of dietary fiber and fat on lymphatic cholesterol and triglyceride absorption in rats

I. Ikeda, Y. Tomari, M. Sugano

Research output: Contribution to journalArticle

112 Citations (Scopus)

Abstract

Lymph cannulated rats were administered intragastrically a test emulsion containing 25 mg of [14C]cholesterol, 50 mg of either guar gum, cellulose or chitosan, and 200 mg of either safflower, high-oleic safflower or palm oil, and the absorption of labeled cholesterol and fatty acids was measured. The type of both dietary fiber (P < 0.001) and fat (P < 0.05) significantly influenced cholesterol absorption. A significant interaction of fiber and fat on cholesterol absorption (P < 0.05) was also observed. Chitosan effectively lowered cholesterol absorption more than did guar gum or cellulose, and this effect was more significant when given with safflower or high-oleic safflower oil than with palm oil. When guar gum was the source of dietary fat, dietary fats did not modify cholesterol absorption. Dietary fiber also significantly affected triglyceride absorption (P < 0.05). Absorption tended to be low in the chitosan, high in the cellulose and intermediate in the guar gum group. Absorption of safflower and high-oleic safflower oils tended to be higher than that of palm oil when cellulose or guar gum was fed. Guar gum, as compared with the other fibers, altered the absorption pattern of both cholesterol and triglyceride. The results showed that the type of dietary fat significantly influenced the effect that dietary fiber exerted on lipid absorption.

Original languageEnglish
Pages (from-to)1383-1387
Number of pages5
JournalJournal of Nutrition
Volume119
Issue number10
DOIs
Publication statusPublished - 1989 Jan 1
Externally publishedYes

Keywords

  • Cholesterol
  • Dietary fat
  • Dietary fiber
  • Lipid absorption
  • Male rats

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'Interrelated effects of dietary fiber and fat on lymphatic cholesterol and triglyceride absorption in rats'. Together they form a unique fingerprint.

  • Cite this