TY - JOUR
T1 - Interplay of transcription factors in T-cell differentiation and function
T2 - The role of Runx
AU - Wong, Won Fen
AU - Kohu, Kazuyoshi
AU - Chiba, Tomoki
AU - Sato, Takehito
AU - Satake, Masanobu
PY - 2011/2
Y1 - 2011/2
N2 - Over the past years, increasing numbers of distinct subsets have been discovered and identified for a T lymphocytes' entity. Differentiation and function of each T cell subset are controlled by a specific master transcription factor. Importantly, Runt-related transcription factors, particularly Runx1 and Runx3, interplay with these master regulators in various aspects of T cells' immunity. In this review article, we first explain roles of Th-Pok and Runx3 in differentiation of CD4 versus CD8 single positive cells, and later focus on cross-regulation of Th-Pok and Runx3 and their relationship with other factors such as TCR strength. Next, we provide evidences for the direct interplay of Runx1/3 with T-bet and GATA3 during Th1 versus Th2 commitment to activate or silence transcription of signature cytokine genes, IFNγ and IL4. Lastly, we explain feed-forward relationship between Runx1 and Foxp3 and discuss roles of Runx1 in regulatory T cells' suppressive activity. This review highlights an essential importance of Runx molecules in controlling various T cell subsets' differentiation and functions through molecular interplay with the master transcription factors in terms of protein-protein interaction as well as regulation of gene expression.
AB - Over the past years, increasing numbers of distinct subsets have been discovered and identified for a T lymphocytes' entity. Differentiation and function of each T cell subset are controlled by a specific master transcription factor. Importantly, Runt-related transcription factors, particularly Runx1 and Runx3, interplay with these master regulators in various aspects of T cells' immunity. In this review article, we first explain roles of Th-Pok and Runx3 in differentiation of CD4 versus CD8 single positive cells, and later focus on cross-regulation of Th-Pok and Runx3 and their relationship with other factors such as TCR strength. Next, we provide evidences for the direct interplay of Runx1/3 with T-bet and GATA3 during Th1 versus Th2 commitment to activate or silence transcription of signature cytokine genes, IFNγ and IL4. Lastly, we explain feed-forward relationship between Runx1 and Foxp3 and discuss roles of Runx1 in regulatory T cells' suppressive activity. This review highlights an essential importance of Runx molecules in controlling various T cell subsets' differentiation and functions through molecular interplay with the master transcription factors in terms of protein-protein interaction as well as regulation of gene expression.
KW - Cell differentiation
KW - Gene expression
KW - Gene targeting
KW - T lymphocytes
KW - Transcription factor
UR - http://www.scopus.com/inward/record.url?scp=78650947473&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650947473&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2567.2010.03381.x
DO - 10.1111/j.1365-2567.2010.03381.x
M3 - Review article
C2 - 21091910
AN - SCOPUS:78650947473
VL - 132
SP - 157
EP - 164
JO - Immunology
JF - Immunology
SN - 0019-2805
IS - 2
ER -