Internal distribution of micro-/nano-sized ceramics and metals particles in mice

Shigeaki Abe, Ikuhiro Kida, Mitsue Esaki, Nobuki Iwadera, Mami Mutoh, Chika Koyama, Tsukasa Akasaka, Motohiro Uo, Yoshinori Kuboki, Manabu Morita, Yoshinori Sato, Koichi Haneda, Tetsu Yonezawa, Balachandran Jeyadevan, Kazuyuki Tohji, Fumio Watari

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Internal distribution of several nanoparticles in mice has been investigated using scanning X-ray analytical microscopy, magnetic resonance imaging and inductively coupled plasmaatomic emission spectroscopy. According dynamic laser scattering analysis, the actual particle size of obtained metal oxide was similar to that of metal particles. The estimated diameters were ca. one micrometer. After administration through the tail vein of the mice, metal particles quickly reached some organs. The distribution ratio reached a constant value and was then maintained. On the other hand, the metal oxide particles were first localized in the spleen and lung. The concentration in the lung was decreased with post-injection time. This result suggested that the particles were temporally trapped in the lung then removed to other organs. The behaviors between metal and metal oxide were quite different even when those particles had a similar actual particle size. Therefore, the distribution behavior of particles depended on the chemical species.

Original languageEnglish
Pages (from-to)525-529
Number of pages5
JournalJournal of the Ceramic Society of Japan
Volume118
Issue number1378
DOIs
Publication statusPublished - 2010 Jun

Keywords

  • Biodistribution
  • Chemical species
  • Magnetic resonance imaging
  • Metal oxides
  • Micro-/nano-sized particles
  • Timedependence

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemistry(all)
  • Condensed Matter Physics
  • Materials Chemistry

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  • Cite this

    Abe, S., Kida, I., Esaki, M., Iwadera, N., Mutoh, M., Koyama, C., Akasaka, T., Uo, M., Kuboki, Y., Morita, M., Sato, Y., Haneda, K., Yonezawa, T., Jeyadevan, B., Tohji, K., & Watari, F. (2010). Internal distribution of micro-/nano-sized ceramics and metals particles in mice. Journal of the Ceramic Society of Japan, 118(1378), 525-529. https://doi.org/10.2109/jcersj2.118.525