Interleukin-6 (IL-6) producing phaeochromocytoma: Direct IL-6 suppression by non-steroidal anti-inflammatory drugs

Chikara Shimizu, Mitsumasa Kubo, Kazuhiko Takano, Akiko Takano, Hiromichi Kijima, Hiroshi Saji, Itaru Katsuyama, Hironobu Sasano, Takao Koike

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30 Citations (Scopus)


A 35-year-old Japanese woman presented with a phaeochromocytoma and demonstrated marked inflammatory reactions and pyrexia as a result of excessive production of interleukin-6 (IL-6) by the tumour. Serum IL-6 level was 262 ng/l (normal; < 4.0 ng/l). Fever and inflammatory markers were largely overcome by the administration of the non-steroidal anti-inflammatory drug, naproxen, and all symptoms disappeared soon after the tumour was excised. Immunohistochemical study revealed positive staining using an antihuman IL-6 antibody and Northern analysis showed increased IL-6 mRNA levels in the tumour. Cultured tumour cells showed IL-6 protein synthesis, and nonsteroidal anti-inflammatory drugs such as naproxen and indomethacin directly inhibited IL-6 release. These results indicate that the effects of naproxen in vivo were due, at least in part, to direct suppression of IL-6 secretion from the tumour.

Original languageEnglish
Pages (from-to)405-410
Number of pages6
JournalClinical Endocrinology
Issue number3
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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