Abstract
We have investigated the role of JAK3 in interleukin 2 (IL-2)-induced signal transduction with a human T cell line, ED40515(-), lacking expression of the IL-2 receptor γ chain and its sublines transfected with wild-type or mutant cDNAs of the IL-2 receptor γ chain. Our results demonstrated that the membrane-proximal cytoplasmic region, encompassing the src homology region 2 (SH2)-like subdomain, of the γ chain is essential for association and activation of JAK3. Furthermore, IL-2-induced activation of JAK3 paralleled induction of the c-myc gene and DNA synthesis but not induction of the c-fos and c-jun genes. These results support the hypothesis that JAK3 plays a pivotal role in the IL-2 receptor-mediated signals for cell growth.
| Original language | English |
|---|---|
| Pages (from-to) | 201-206 |
| Number of pages | 6 |
| Journal | FEBS Letters |
| Volume | 351 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1994 Sep 5 |
Keywords
- IL-2
- IL-2Rγ
- JAK3
- Signal transduction
ASJC Scopus subject areas
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology
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Cite this
Asao, H., Tanaka, N., Ishii, N., Higuchi, M., Takeshita, T., Nakamura, M., Shirasawa, T., & Sugamura, K. (1994). Interleukin 2-induced activation of JAK3: Possible involvement in signal transduction for c-myc induction and cell proliferation. FEBS Letters, 351(2), 201-206. https://doi.org/10.1016/0014-5793(94)00831-0