Interleukin 2-induced activation of JAK3: Possible involvement in signal transduction for c-myc induction and cell proliferation

Hironobu Asao, Nobuyuki Tanaka, Naoto Ishii, Masaya Higuchi, Toshikazu Takeshita, Masataka Nakamura, Takuji Shirasawa, Kazuo Sugamura

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

We have investigated the role of JAK3 in interleukin 2 (IL-2)-induced signal transduction with a human T cell line, ED40515(-), lacking expression of the IL-2 receptor γ chain and its sublines transfected with wild-type or mutant cDNAs of the IL-2 receptor γ chain. Our results demonstrated that the membrane-proximal cytoplasmic region, encompassing the src homology region 2 (SH2)-like subdomain, of the γ chain is essential for association and activation of JAK3. Furthermore, IL-2-induced activation of JAK3 paralleled induction of the c-myc gene and DNA synthesis but not induction of the c-fos and c-jun genes. These results support the hypothesis that JAK3 plays a pivotal role in the IL-2 receptor-mediated signals for cell growth.

Original languageEnglish
Pages (from-to)201-206
Number of pages6
JournalFEBS Letters
Volume351
Issue number2
DOIs
Publication statusPublished - 1994 Sep 5

Keywords

  • IL-2
  • IL-2Rγ
  • JAK3
  • Signal transduction

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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