TY - JOUR
T1 - Interleukin 2-induced activation of JAK3
T2 - Possible involvement in signal transduction for c-myc induction and cell proliferation
AU - Asao, Hironobu
AU - Tanaka, Nobuyuki
AU - Ishii, Naoto
AU - Higuchi, Masaya
AU - Takeshita, Toshikazu
AU - Nakamura, Masataka
AU - Shirasawa, Takuji
AU - Sugamura, Kazuo
N1 - Funding Information:
Acknowledgements. This work was supported in part by Grants-in-Aid for General Science Research and for Scientific Research on Priority Areas from the Ministry of Education, Science and Culture, by a grant form Special Coordination Funds of Science and Technology Agency of the Japanese Government, and by grants from the Naito Foundation and the Mochida Memorial Foundation for Medical and Pharmaceutical Research.
PY - 1994/9/5
Y1 - 1994/9/5
N2 - We have investigated the role of JAK3 in interleukin 2 (IL-2)-induced signal transduction with a human T cell line, ED40515(-), lacking expression of the IL-2 receptor γ chain and its sublines transfected with wild-type or mutant cDNAs of the IL-2 receptor γ chain. Our results demonstrated that the membrane-proximal cytoplasmic region, encompassing the src homology region 2 (SH2)-like subdomain, of the γ chain is essential for association and activation of JAK3. Furthermore, IL-2-induced activation of JAK3 paralleled induction of the c-myc gene and DNA synthesis but not induction of the c-fos and c-jun genes. These results support the hypothesis that JAK3 plays a pivotal role in the IL-2 receptor-mediated signals for cell growth.
AB - We have investigated the role of JAK3 in interleukin 2 (IL-2)-induced signal transduction with a human T cell line, ED40515(-), lacking expression of the IL-2 receptor γ chain and its sublines transfected with wild-type or mutant cDNAs of the IL-2 receptor γ chain. Our results demonstrated that the membrane-proximal cytoplasmic region, encompassing the src homology region 2 (SH2)-like subdomain, of the γ chain is essential for association and activation of JAK3. Furthermore, IL-2-induced activation of JAK3 paralleled induction of the c-myc gene and DNA synthesis but not induction of the c-fos and c-jun genes. These results support the hypothesis that JAK3 plays a pivotal role in the IL-2 receptor-mediated signals for cell growth.
KW - IL-2
KW - IL-2Rγ
KW - JAK3
KW - Signal transduction
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U2 - 10.1016/0014-5793(94)00831-0
DO - 10.1016/0014-5793(94)00831-0
M3 - Article
C2 - 8082765
AN - SCOPUS:0028101830
VL - 351
SP - 201
EP - 206
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 2
ER -