Interleukin-2 (IL-2) induces erythroid differentiation and tyrosine phosphorylation in ELM-I-1 cells transfected with a human IL-2 receptor β chain cDNA

Kazunori Imada, Mitsuru Tsudo, Tai ichi Kodaka, Katsuhiko Itoh, Nobuyoshi Arima, Toshio Hattori, Minoru Okuma, Takashi Uchiyama

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The molecular mechanism of erythroid differentiation has been still ill-defined. In this study, we introduced a human interleukin-2 receptor (IL-2R) β chain cDNA into ELM-I-1 cells which differentiated into hemoglobin-positive cells in the presence of erythropoietin (Epo), and established the transformant which expressed IL-2R β chain. In this transformant, we revealed that IL-2 induced erythroid differentiation and the same pattern of tyrosine phosphorylation as Epo. These data suggest that tyrosine phosphorylation is involved in signal transduction pathway of erythroid differentiation. It is also implicated that the Epo and IL-2 receptor system share a common signal transduction pathway.

Original languageEnglish
Pages (from-to)352-357
Number of pages6
JournalBiochemical and biophysical research communications
Volume188
Issue number1
DOIs
Publication statusPublished - 1992 Oct 15

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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