Interleukin-18 (IL-18) synergizes with IL-2 to enhance cytotoxicity, interferon-γ production, and expansion of natural killer cells

Young Ik Son; Ramsey M. Dallal; Robbie B. Mailliard; Shinichi Egawa; Zdenka L. Jonak; Michael T. Lotze

Interleukin-18 (IL-18) synergizes with IL-2 to enhance cytotoxicity, interferon-γ production, and expansion of natural killer cells

Young Ik Son, Ramsey M. Dallal, Robbie B. Mailliard, Shinichi Egawa, Zdenka L. Jonak, Michael T. Lotze

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated the in vitro effects of combining interleukin-18 (IL-18) and IL-2 on human lymphocytes. The combined use of these two cytokines synergistically enhanced the proliferation, cytolytic activity, and interferon-γ production of peripheral blood mononuclear cells. Phenotypic analysis revealed a preferential expansion of CD56⁺CD3^-cells and an upregulation of IL-2 receptor-α expression on natural killer cells. Isolated natural killer cells showed a substantial increase in proliferation and cytotoxicity compared with CD4⁺and CD8⁺T cells. The combined use of IL-18 and IL-2 should be considered a viable strategy to induce an antitumor response in vivo.

Original language	English
Pages (from-to)	884-888
Number of pages	5
Journal	Cancer Research
Volume	61
Issue number	3
Publication status	Published - 2001 Feb 1
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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Interleukin-18 (IL-18) synergizes with IL-2 to enhance cytotoxicity, interferon-γ production, and expansion of natural killer cells. / Son, Young Ik; Dallal, Ramsey M.; Mailliard, Robbie B.; Egawa, Shinichi; Jonak, Zdenka L.; Lotze, Michael T.

In: Cancer Research, Vol. 61, No. 3, 01.02.2001, p. 884-888.

Research output: Contribution to journal › Article › peer-review

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