Interleukin-18 (IL-18) synergizes with IL-2 to enhance cytotoxicity, interferon-γ production, and expansion of natural killer cells

Young Ik Son, Ramsey M. Dallal, Robbie B. Mailliard, Shinichi Egawa, Zdenka L. Jonak, Michael T. Lotze

Research output: Contribution to journalArticlepeer-review

92 Citations (Scopus)

Abstract

We investigated the in vitro effects of combining interleukin-18 (IL-18) and IL-2 on human lymphocytes. The combined use of these two cytokines synergistically enhanced the proliferation, cytolytic activity, and interferon-γ production of peripheral blood mononuclear cells. Phenotypic analysis revealed a preferential expansion of CD56+CD3-cells and an upregulation of IL-2 receptor-α expression on natural killer cells. Isolated natural killer cells showed a substantial increase in proliferation and cytotoxicity compared with CD4+and CD8+T cells. The combined use of IL-18 and IL-2 should be considered a viable strategy to induce an antitumor response in vivo.

Original languageEnglish
Pages (from-to)884-888
Number of pages5
JournalCancer Research
Volume61
Issue number3
Publication statusPublished - 2001 Feb 1
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Interleukin-18 (IL-18) synergizes with IL-2 to enhance cytotoxicity, interferon-γ production, and expansion of natural killer cells'. Together they form a unique fingerprint.

Cite this