Significant progress in interleukin-17 research over the last 5 years has established this cytokine as a molecule of tremendous functional potential, and complexity. At least four new members structurally related to IL-17 have been identified, thus establishing a family of IL-7-related molecules. The IL-17 family of proteins, produced predominantly by activated T cells, exhibits a broad range of activities, and is represented in a spectrum of pathophysiologic conditions. The chapter provides ample of evidence for IL-17 as a regulator of hematopoiesis, and as a mediator of inflammation in several T cell-mediated disorders. These observations necessitate further research and development of this cytokine for potential clinical applications for conditions associated with compromised BM status, as well as in transplantation, cancer, autoimmunity, and other T cell-mediated inflammatory disorders.
ASJC Scopus subject areas
- Immunology and Microbiology(all)