TY - JOUR
T1 - Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma
AU - Kawano, M.
AU - Tanaka, H.
AU - Ishikawa, H.
AU - Nobuyoshi, M.
AU - Iwato, K.
AU - Asaoku, H.
AU - Tanabe, O.
AU - Kuramoto, A.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1989
Y1 - 1989
N2 - Recombinant interleukin 1α (rIL-1α) augmented proliferation of freshly isolated myeloma cells as well as B-cell stimulatory factor 2 (BSF-2)/interleukin-6 (IL-6). Recombinant IL-1α-induced proliferation was partially inhibited by anti-IL-6 antibody. In the culture supernatants of rIL-1α-stimulated myeloma cells, IL-6 activities, which were measured by using an IL-6-dependent murine hybridoma clone, MH60.BSF2, were increased, when compared with those in the culture supernatants of nonstimulated myeloma cells. Furthermore, IL-6-messenger RNA (mRNA) expression was also augmented in IL-1α-stimulated myeloma cells. Therefore rIL-1α stimulates myeloma cells to produce IL-6, which consequently augments proliferation of myeloma cells. Thus, IL-1 can accelerate autocrine growth of myeloma cells through IL-6.
AB - Recombinant interleukin 1α (rIL-1α) augmented proliferation of freshly isolated myeloma cells as well as B-cell stimulatory factor 2 (BSF-2)/interleukin-6 (IL-6). Recombinant IL-1α-induced proliferation was partially inhibited by anti-IL-6 antibody. In the culture supernatants of rIL-1α-stimulated myeloma cells, IL-6 activities, which were measured by using an IL-6-dependent murine hybridoma clone, MH60.BSF2, were increased, when compared with those in the culture supernatants of nonstimulated myeloma cells. Furthermore, IL-6-messenger RNA (mRNA) expression was also augmented in IL-1α-stimulated myeloma cells. Therefore rIL-1α stimulates myeloma cells to produce IL-6, which consequently augments proliferation of myeloma cells. Thus, IL-1 can accelerate autocrine growth of myeloma cells through IL-6.
UR - http://www.scopus.com/inward/record.url?scp=0024402804&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024402804&partnerID=8YFLogxK
U2 - 10.1182/blood.v73.8.2145.bloodjournal7382145
DO - 10.1182/blood.v73.8.2145.bloodjournal7382145
M3 - Article
C2 - 2786435
AN - SCOPUS:0024402804
VL - 73
SP - 2145
EP - 2148
JO - Blood
JF - Blood
SN - 0006-4971
IS - 8
ER -