Interleukin-1 accelerates autocrine growth of myeloma cells through interleukin-6 in human myeloma

M. Kawano, H. Tanaka, H. Ishikawa, M. Nobuyoshi, K. Iwato, H. Asaoku, O. Tanabe, A. Kuramoto

Research output: Contribution to journalArticlepeer-review

108 Citations (Scopus)

Abstract

Recombinant interleukin 1α (rIL-1α) augmented proliferation of freshly isolated myeloma cells as well as B-cell stimulatory factor 2 (BSF-2)/interleukin-6 (IL-6). Recombinant IL-1α-induced proliferation was partially inhibited by anti-IL-6 antibody. In the culture supernatants of rIL-1α-stimulated myeloma cells, IL-6 activities, which were measured by using an IL-6-dependent murine hybridoma clone, MH60.BSF2, were increased, when compared with those in the culture supernatants of nonstimulated myeloma cells. Furthermore, IL-6-messenger RNA (mRNA) expression was also augmented in IL-1α-stimulated myeloma cells. Therefore rIL-1α stimulates myeloma cells to produce IL-6, which consequently augments proliferation of myeloma cells. Thus, IL-1 can accelerate autocrine growth of myeloma cells through IL-6.

Original languageEnglish
Pages (from-to)2145-2148
Number of pages4
JournalBlood
Volume73
Issue number8
DOIs
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

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