Mycosis fungoides (MF), a cutaneous T-cell lymphoma, is usually characterized by cell features of T-helper-2 (Th2) lymphocytes. MF has recently been reported to show increased CCR4 expression, a chemokine receptor specifically expressed in Th2. Previously, we have reported the effectiveness of interferon-γ (IFN-γ) for the treatment of CCR4+ MF. In this report, we describe two cases of CD4+, CCR4-MF successfully treated with IFN-α, but not IFN-γ. Although MF usually displays a Th2 profile, the tumor cells in our two cases did not express CCR4. Our cases suggest the effectiveness of IFN-α, but not IFN-γ, for CCR4-MF.
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