TY - JOUR
T1 - Interferon-α is effective for CD4+, CCR4-mycosis fungoides
AU - Fujimura, Taku
AU - Okuyama, Ryuhei
AU - Watabe, Akiko
AU - Hashimoto, Akira
AU - Tagami, Hachiro
AU - Aiba, Setsuya
PY - 2007/4
Y1 - 2007/4
N2 - Mycosis fungoides (MF), a cutaneous T-cell lymphoma, is usually characterized by cell features of T-helper-2 (Th2) lymphocytes. MF has recently been reported to show increased CCR4 expression, a chemokine receptor specifically expressed in Th2. Previously, we have reported the effectiveness of interferon-γ (IFN-γ) for the treatment of CCR4+ MF. In this report, we describe two cases of CD4+, CCR4-MF successfully treated with IFN-α, but not IFN-γ. Although MF usually displays a Th2 profile, the tumor cells in our two cases did not express CCR4. Our cases suggest the effectiveness of IFN-α, but not IFN-γ, for CCR4-MF.
AB - Mycosis fungoides (MF), a cutaneous T-cell lymphoma, is usually characterized by cell features of T-helper-2 (Th2) lymphocytes. MF has recently been reported to show increased CCR4 expression, a chemokine receptor specifically expressed in Th2. Previously, we have reported the effectiveness of interferon-γ (IFN-γ) for the treatment of CCR4+ MF. In this report, we describe two cases of CD4+, CCR4-MF successfully treated with IFN-α, but not IFN-γ. Although MF usually displays a Th2 profile, the tumor cells in our two cases did not express CCR4. Our cases suggest the effectiveness of IFN-α, but not IFN-γ, for CCR4-MF.
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U2 - 10.1111/j.1365-4632.2007.03221.x
DO - 10.1111/j.1365-4632.2007.03221.x
M3 - Article
C2 - 17442093
AN - SCOPUS:34247133577
SN - 0011-9059
VL - 46
SP - 435
EP - 438
JO - International Journal of Dermatology
JF - International Journal of Dermatology
IS - 4
ER -