Abstract
Behaviors of selenite and inorganic mercury and interaction of these compounds in rabbit blood were investigated after intravenous administration. The major portion of the materials, when administered alone, was initially present in the plasma, but the plasma levels decreased rapidly. Simultaneous administration of both compounds caused the elevation of their levels in the erythrocyte. The radioactivity of both mercury and selenium in the erythrocyte showed relatively slow decay during the experiment, while that in the plasma decreased rapidly after a short stable phase of about one hour. Sephadex column chromatography of the stroma free hemolysate indicated an identical pattern of distribution of mercury and selenium as that observed in an in vitro study.
| Original language | English |
|---|---|
| Pages (from-to) | 67-73 |
| Number of pages | 7 |
| Journal | journal of pharmacobio-dynamics |
| Volume | 1 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1978 Jan 1 |
Keywords
- distribution in erythrocyte
- gel-filtration
- in vivo interaction
- inorganic mercury
- rabbit blood
- selenite
ASJC Scopus subject areas
- Pharmacology