Interaction of inorganic mercury and selenite in rabbit blood after intravenous administration

Nobumasa Imura, Akira Naganuma

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Behaviors of selenite and inorganic mercury and interaction of these compounds in rabbit blood were investigated after intravenous administration. The major portion of the materials, when administered alone, was initially present in the plasma, but the plasma levels decreased rapidly. Simultaneous administration of both compounds caused the elevation of their levels in the erythrocyte. The radioactivity of both mercury and selenium in the erythrocyte showed relatively slow decay during the experiment, while that in the plasma decreased rapidly after a short stable phase of about one hour. Sephadex column chromatography of the stroma free hemolysate indicated an identical pattern of distribution of mercury and selenium as that observed in an in vitro study.

Original languageEnglish
Pages (from-to)67-73
Number of pages7
Journaljournal of pharmacobio-dynamics
Volume1
Issue number2
DOIs
Publication statusPublished - 1978 Jan 1

Keywords

  • distribution in erythrocyte
  • gel-filtration
  • in vivo interaction
  • inorganic mercury
  • rabbit blood
  • selenite

ASJC Scopus subject areas

  • Pharmacology

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