Interaction of histamine and calcitonin gene-related peptide in the formalin-induced pain perception in rats

Jalal Izadi Mobarakeh, Anahita Torkaman-Boutorabi, Amir Abbas Rahimi, Shahrooz Ghasri, Reza Mohammad Ali Nezhad, Arash Hamzely, Baharak Khoshkholgh Sima, Kazuhiro Takahashi, Kazuo Nunoki, Kazuhiko Yanai

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Histamine and calcitonin gene-related peptide (CGRP) contribute to the pain perception. The aim of the present study is to clarify the interaction of histamine and CGRP in the perception of inflammatory pain. The effects of a histamine H1 receptor antagonist (pyrilamine, i.p.), an H2 receptor antagonist (ranitidine, i.p.) and a CGRP antagonist (CGRP 8-37, i.t.) on the formalin-induced pain was studied in rats. Pyrilamine and ranitidine produced a dose-dependent antinociceptive response in the first and the second phases of the formalin test. A single administration of pyrilamine (1 mg/kg, i.p.), ranitidine (10 mg/kg, i.p.) or CGRP 8-37 (10 μg/μL, i.t.) had no significant effects on the pain perception in the second phase. A combination of CGRP 8-37 and pyrilamine or ranitidine at these sub-effective doses, however, showed nociceptive response in the second phase. Moreover, a histamine (i.t.)-induced hyperalgesia was completely prevented by treatment with GGRP 8-37 at this dose. Our findings have raised the possibility that the CGRP system has interaction with histamine in the perception of inflammatory pain.

Original languageEnglish
Pages (from-to)195-201
Number of pages7
JournalBiomedical Research
Volume32
Issue number3
DOIs
Publication statusPublished - 2011

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Interaction of histamine and calcitonin gene-related peptide in the formalin-induced pain perception in rats'. Together they form a unique fingerprint.

Cite this