Intensity based methods for brain MRI longitudinal registration. A study on multiple sclerosis patients

Yago Diez, Arnau Oliver, Mariano Cabezas, Sergi Valverde, Robert Martí, Joan Carles Vilanova, Lluís Ramió-Torrentà, Àlex Rovira, Xavier Lladó

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Registration is a key step in many automatic brain Magnetic Resonance Imaging (MRI) applications. In this work we focus on longitudinal registration of brain MRI for Multiple Sclerosis (MS) patients. First of all, we analyze the effect that MS lesions have on registration by synthetically eliminating some of the lesions. Our results show how a widely used method for longitudinal registration such as rigid registration is practically unconcerned by the presence of MS lesions while several non-rigid registration methods produce outputs that are significantly different. We then focus on assessing which is the best registration method for longitudinal MRI images of MS patients. In order to analyze the results obtained for all studied criteria, we use both descriptive statistics and statistical inference: one way ANOVA, pairwise t-tests and permutation tests.

Original languageEnglish
Pages (from-to)365-379
Number of pages15
JournalNeuroinformatics
Volume12
Issue number3
DOIs
Publication statusPublished - 2014 Jul

Keywords

  • Brain MRI
  • Longitudinal analysis
  • Multiple sclerosis
  • Registration

ASJC Scopus subject areas

  • Software
  • Neuroscience(all)
  • Information Systems

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  • Cite this

    Diez, Y., Oliver, A., Cabezas, M., Valverde, S., Martí, R., Vilanova, J. C., Ramió-Torrentà, L., Rovira, À., & Lladó, X. (2014). Intensity based methods for brain MRI longitudinal registration. A study on multiple sclerosis patients. Neuroinformatics, 12(3), 365-379. https://doi.org/10.1007/s12021-013-9216-z