Integration of chemical and biochemical analysis systems into a glass microchip

Kiichi Sato, Akihide Hibara, Manabu Tokeshi, Hideaki Hisamoto, Takehiko Kitamori

Research output: Contribution to journalReview article

61 Citations (Scopus)

Abstract

This review focuses on the integration of chemical and biochemical analysis systems into glass microchips for general use. By combining multiphase laminar flow driven by pressure and micro unit operations, such as mixing, reaction, extraction and separation, continuous-flow chemical processing systems can be realized in the microchip format, while the application of electrophoresis-based chip technology is limited. The performances of several analysis systems were greatly improved by microchip integration because of some characteristics of microspace, i.e., a large specific interface area, a short molecular diffusion time, a small heat capacity and so on. By applying these concepts, several different analysis systems, i.e., wet analysis of cobalt ion, multi-ion sensor, immunoassay, and cellular analysis, were successfully integrated on a microchip. These microchip technologies are promising for meeting the future demands of high-throughput chemical processing.

Original languageEnglish
Pages (from-to)15-22
Number of pages8
Journalanalytical sciences
Volume19
Issue number1
DOIs
Publication statusPublished - 2003 Jan 1

ASJC Scopus subject areas

  • Analytical Chemistry

Fingerprint Dive into the research topics of 'Integration of chemical and biochemical analysis systems into a glass microchip'. Together they form a unique fingerprint.

  • Cite this