Integrated fluidic systems on a nanometer scale and the study on behavior of liquids in small confinement

Akihide Hibara, Takehiko Tsukahara, Takehiko Kitamori

Research output: Contribution to journalReview article

17 Citations (Scopus)

Abstract

Nanofluidic systems and the studies on the behavior of liquids confined in nanometer-sized space are reviewed. Miniaturized chemical systems having nanometer-sized structures are fabricated by using advanced nanofabrication techniques. The size-confinement effect is expected to be applied in well-controlled chemical and biochemical analysis. While electroosmosis and electrokinetic migration in small-sized channels have been investigated extensively, there have been few reports on pressure-driven flow systems having nanometer-sized structures, which are widely used in laboratory-scale and micrometer-sized systems. In this review, fundamental technologies that can be used in integrated chemical analysis systems having nanometer-sized structures are introduced. In addition to the technological investigations, important topics in the fundamental research on the properties of liquids confined in nanometer-sized space are also presented.

Original languageEnglish
Pages (from-to)673-683
Number of pages11
JournalJournal of Chromatography A
Volume1216
Issue number4
DOIs
Publication statusPublished - 2009 Jan 23
Externally publishedYes

Keywords

  • Capillary introduction
  • Microchip
  • Nanofluidics
  • Nanometer-sized channel
  • Pressure-driven flow

ASJC Scopus subject areas

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

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