Intake of mulberry 1-deoxynojirimycin prevents colorectal cancer in mice

E. Shuang, Kazushi Yamamoto, Yu Sakamoto, Yui Mizowaki, Yui Iwagaki, Toshiyuki Kimura, Kiyotaka Nakagawa, Teruo Miyazawa, Tsuyoshi Tsuduki

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

Theeffectof 1-deoxynojirimycin,a caloricrestriction mimetic,was examined in ICR mice with azoxymethane dextran sodium sulfate-induced colorectal cancer. Azoxymethane is a carcinogen (10 mg/kg body weight), and 2% dextran sodium sulfate (w/v) used as a colitis-inducing agent. Mice were separated into 5 groups: a group without colorectal cancer fed a normal diet (CO- group), and groups with colorectal cancer fed a normal diet (CO+ group), a calorie-restricted diet (caloric restriction group), and diets including 0.02% and 0.1% 1-deoxynojirimycin (L-1-deoxynojirimycin and H-1-deoxynojirimycin groups). The tumor incidence and number were reduced significantly in the caloric restriction group compared to the CO+ group, and were also suppressed in a dose-dependent manner by 1-deoxynojirimycin. mRNA for anti-apoptotic Bcl-2 was decreased and that for pro-apoptotic Bax was increased in the carcinoma tissue of CR, L-1-deoxynojirimycin and H-1-deoxynojirimycin groups. These results suggest that caloric restriction and 1-deoxynojirimycin inhibit growth of colorectal cancer by inducing apoptosis in an induced cancer model in mice.

Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalJournal of Clinical Biochemistry and Nutrition
Volume61
Issue number1
DOIs
Publication statusPublished - 2017 Jul

Keywords

  • 1-deoxynojirimycin
  • Azoxymethane
  • Caloric restriction
  • Colorectal cancer
  • Dextran sodium sulfate

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

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