Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1

Marine Champsaur, Joshua N. Beilke, Kouetsu Ogasawara, Ulrich H. Koszinowski, Stipan Jonjic, Lewis L. Lanier

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Human tumors frequently express membrane-bound or soluble NK group 2, member D (NKG2D) ligands. This results in chronic engagement of NKG2D on the surfaces of NK and CD8+ T cells and rapid internalization of the receptor. Although it is well appreciated that this phenomenon impairs NKG2D-dependent function, careful analysis of NKG2D-independent functions in cells chronically stimulated through NKG2D is lacking. Using a mouse model of chronic NKG2D ligand expression, we show that constant exposure to NKG2D ligands does not functionally impair NK cells and CD8+ T cells in the context of viral infection.

Original languageEnglish
Pages (from-to)157-165
Number of pages9
JournalJournal of Immunology
Volume185
Issue number1
DOIs
Publication statusPublished - 2010 Jul 1

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint Dive into the research topics of 'Intact NKG2D-independent function of NK cells chronically stimulated with the NKG2D ligand Rae-1'. Together they form a unique fingerprint.

Cite this