Insulin-releasing effect of quinaldic acid and its relatives on isolated Langerhans islets

Hiroshi Okamoto, Susumu Miyamoto, Hiroshi Mabuchi, Yoshimasa Yoneyama, Ryoyu Takeda

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Quinaldic acid and 8-hydroxyquinaldic acid, end-metabolites of kynurenine (1,2), were shown to cause release of insulin from isolated Langerhans islets of rats. In this respect, both kynurenic acid and xanthurenic acid were found to be somewhat less active than quinaldic acid, but L-kynurenine, 3-hydroxyl-L-kynurenine, quinolinic acid and L-tryptophan did not cause the insulin release. Possible correlation between disorder in tryptophan metabolisms directed toward the excessive formation of quinaldic acid and 8-hydroxyquinaldic acid and pathogenesis of diabetic state was discussed.

Original languageEnglish
Pages (from-to)1297-1303
Number of pages7
JournalBiochemical and biophysical research communications
Volume53
Issue number4
DOIs
Publication statusPublished - 1973 Aug 21
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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