Innovative, replaceable heart valve: Concept, in vitro study, and acute in vivo study

Kiyotaka Fukamachi, Yoshio Ootaki, Chiyo Ootaki, Masatoshi Akiyama, Keiji Kamohara, Faruk Cingoz, Ji Feng Chen, David J. Horvath, Alex L. Massiello, Raymond Dessoffy

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


The purpose of this study was to evaluate the feasibility of our innovative, replaceable heart valves that can be easily detached from the sewing ring at the time of repeat replacement. The prototype devices consist of the base magnet ring assembly and the valve magnet ring assembly that utilize magnetic coupling force for the locking mechanism. Magnetic coupling strength was evaluated in vitro. Prototype bioprosthetic valves were implanted acutely in three sheep to confirm the feasibility of the replaceable mitral valve. The static separation force of prototype size #25 was 12.5 lb, meeting the design goal. In situ attachment and detachment of the valve magnet ring assembly from the base magnet ring assembly were very easily accomplished in all animals. The magnetic coupling did not decouple even under extremely high left ventricular pressures. We have demonstrated the feasibility of this innovative concept of a replaceable mitral valve.

Original languageEnglish
Pages (from-to)226-229
Number of pages4
JournalArtificial Organs
Issue number3
Publication statusPublished - 2008 Mar
Externally publishedYes


  • Bioprosthesis
  • Prosthetic valve
  • Reoperation
  • Valve replacement

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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