Inner blood-retinal barrier transporters: Role of retinal drug delivery

Ken Ichi Hosoya, Masanori Tachikawa

Research output: Contribution to journalReview articlepeer-review

59 Citations (Scopus)

Abstract

The inner blood-retinal barrier (inner BRB) forms complex tight junctions of retinal capillary endothelial cells to prevent the free diffusion of substances between the circulating blood and the neural retina. Thus, understanding of the inner BRB transport mechanisms could provide a basis for the development of strategies for drug delivery to the retina. Recent progress in inner BRB research has revealed that retinal endothelial cells express a variety of unique transporters which play a role in the influx transport of essential molecules and the efflux transport of xenobiotics. In this review we focus on the transport mechanism at the inner BRB in relation to its importance in influencing the inner BRB permeability of drugs.

Original languageEnglish
Pages (from-to)2055-2065
Number of pages11
JournalPharmaceutical research
Volume26
Issue number9
DOIs
Publication statusPublished - 2009 Sep 1
Externally publishedYes

Keywords

  • Carrier-mediated transport
  • Efflux transport
  • Influx transport
  • Inner blood-retinal barrier
  • Retinal capillary endothelial cells
  • Transporter

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Organic Chemistry
  • Molecular Medicine
  • Pharmacology (medical)
  • Biotechnology
  • Pharmacology

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