Injectable polymeric nanosheets for subretinal cell delivery

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Age-related macular degeneration (AMD) is one of the major ophthalmic diseases that cause visual impairment and blindness. Although transplantation of autologous peripheral cells has been attempted by injecting cell suspensions, limited visual improvement resulted due to the low viability of the injected cells in the subretinal tissue. We developed micropatterned polymeric nanosheets toward local delivery of retinal pigment epithelial (RPE) cells. The micropatterned nanosheet directed growth and morphogenesis of the RPE cells, and allowed for the injection of an engineered RPE monolayer through syringe needles flexibly into the subretinal space of rat eyes. Such an ultra-thin flexible carrier has the promise of a minimally invasive delivery of organized cellular structures into narrow tissue spaces.

Original languageEnglish
Title of host publication16th International Conference on Nanotechnology - IEEE NANO 2016
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages267-269
Number of pages3
ISBN (Electronic)9781509039142
DOIs
Publication statusPublished - 2016 Nov 21
Event16th IEEE International Conference on Nanotechnology - IEEE NANO 2016 - Sendai, Japan
Duration: 2016 Aug 222016 Aug 25

Publication series

Name16th International Conference on Nanotechnology - IEEE NANO 2016

Other

Other16th IEEE International Conference on Nanotechnology - IEEE NANO 2016
CountryJapan
CitySendai
Period16/8/2216/8/25

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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