Initiation of Ca-spikes from an insect muscle fiber immersed in a low pH saline solution containing carboxylic anions

Jun Fukuda, Kazuyoshi Kawa

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Skeletal muscle fibers of beetle larvae, Xylotrupes dichotomus L., which were inexcitable in the standard saline solution at pH 7.4 became capable of generating all-or-none spikes when a certain amount of acetate was added to a low pH saline solution. The optimum condition for the spike initiation was the presence of 20-30 mM acetate at pH 6. The spikes thus elicited were pure Ca-spikes as they were dependent on the external Ca++ concentration but were not inhibited either by removal of the external Na+ or by application of tetrodotoxin. This facilitation of the Ca-spike generation was probably due to a combined action of acetate and of the low pH upon the muscle membrane.

Original languageEnglish
Pages (from-to)981-987
Number of pages7
JournalLife Sciences
Volume21
Issue number7
DOIs
Publication statusPublished - 1977 Oct 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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