Initiation of alveolar ridge augmentation in the rat mandible by subperiosteal implantation of octacalcium phosphate

Shinji Kamakura, Yasuyuki Sasano, Masanori Nakamura, Osamu Suzuki, Hidetaka Ohki, Manabu Kagayama, Katsutoshi Motegi

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37 Citations (Scopus)

Abstract

The study was designed to investigate the process of bone formation caused by implantation of octacalcium phosphate as well as stability of the bone formed at the alveolar ridge. Synthetic octacalcium phosphate was implanted into a subperiosteal pocket in the rat mandible. Bone formation at the alveolar ridge was examined radiographically and histologically between 1 and 48 week(s) after implantation. Radiopacity of the octacalcium phosphate implant became obvious in week 2. Osteogenesis was initiated from the bone surface near the implantation site and multinucleated giant cells appeared on the implanted octacalcium phosphate in week 1. More apposition of new bone was observed on the implanted octacalcium phosphate in week 2 or later. Some implants were directly enclosed by newly formed bone and no cellular component was seen between the implant and the bone matrix. Many octacalcium phosphate implants were enclosed by bone, whereas the augmented ridge was not seen radiographically in week 24 or later. If its persistence can be improved, octacalcium phosphate could be used to augment atrophic alveolar ridges.

Original languageEnglish
Pages (from-to)1029-1038
Number of pages10
JournalArchives of Oral Biology
Volume41
Issue number11
DOIs
Publication statusPublished - 1996 Nov

Keywords

  • bone formation
  • multinucleated giant cell
  • octacalcium phosphate
  • ridge augmentation
  • subperiosteal implantation

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Dentistry(all)
  • Cell Biology

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