Initial organ distribution and biological safety of Mg 2+ released from a Mg alloy implant

Akimitsu Sato, Yoshinaka Shimizu, Yoshimichi Imai, Toshiji Mukai, Akiko Yamamoto, Chieko Miura, Kenji Muraki, Yuya Sano, Naoko Ikeo, Masahiro Tachi

Research output: Contribution to journalArticlepeer-review

Abstract

Magnesium (Mg) alloys are considered promising materials for biodegradable medical devices; however, the initial effects and distribution of released Mg 2+ ions following implantation are unclear. This is addressed in the present study, using two types of Mg alloys implanted into rats. An in vitro immersion test was first carried out to quantify Mg 2+ ions released from the alloys at early stages. Based on these data, we performed an in vivo experiment in which large amounts of alloys were subcutaneously implanted into the backs of rats for 1, 5, 10, and 25 h. Mg 2+ accumulation in organs was measured by inductively coupled plasma mass spectrometry. In vivo, blood and urine Mg 2+ concentrations were higher in rats receiving the implants than in controls after 1 h; however, the levels were within clinically accepted guidelines. The Mg 2+ concentration in bone was significantly higher in the 25 h implanted group than in the other groups. Our results suggest that homeostasis is maintained by urinary excretion and bone accumulation of released Mg 2+ ions in response to sudden changes in Mg 2+ ion concentration in the body fluid in a large number of Mg alloy implants at the early stages.

Original languageEnglish
Article number035006
JournalBiomedical Materials (Bristol)
Volume13
Issue number3
DOIs
Publication statusPublished - 2018 Mar 6

Keywords

  • biodegradable
  • biological safety
  • implantation
  • inductively coupled plasma mass spectrometry
  • magnesium
  • magnesium alloy
  • organ distribution

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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