Initial acute in vivo performance of the Cleveland Clinic PediPump left ventricular assist device

Diyar Saeed, Stephan Weber, Yoshio Ootaki, Nicole Mielke, Chiyo Ootaki, Masatoshi Akiyama, Tetsuya Horai, Jacquelyn Catanese, Fumoto Hideyuki, Raymond Dessoffy, David T. Dudzinski, Lei Gu, Fernando Casas, William A. Smith, Kiyotaka Fukamachi, Brian W. Duncan

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The PediPump is a small ventricular assist device (VAD) with a hydraulic output range designed to support children from newborns to adolescents. The present report describes our initial evaluation of the PediPump as a left VAD in an acute sheep model. The PediPump was implanted in two sheep (50.8 and 62.7 kg). Pump speed was adjusted to achieve a flow of 2 L/min with the naturally occurring preload and afterload conditions to evaluate pump performance under a steady hemodynamic state for 4 hours. Upon completion, pump performance was evaluated under various blood pressure and heart rate conditions. During steady-state evaluations, the ascending aortic flow and pump speed varied slightly depending on systemic arterial pressure variations. During the hemodynamic manipulation studies, flows ranged between 0.5 and 3.2 L/min with pump speeds of 5,200-16,200 rpm and motor current of 0.06-0.75 A. The PediPump demonstrated good initial hemodynamic performance for use as an implantable left VAD. However, some depositions were detected at the time of explanation, mainly at the rear of the pump. We are continuing with further acute studies to evaluate pump performance in anticipation of beginning chronic studies to evaluate long-term biocompatibility.

Original languageEnglish
Pages (from-to)766-770
Number of pages5
JournalASAIO Journal
Volume53
Issue number6
DOIs
Publication statusPublished - 2007 Nov 1
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

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