Initial Acute Animal Experiment Using a New Miniature Axial Flow Pump in Series With the Natural Heart

Eiji Okamoto, Tetsuya Yano, Yasuyuki Shiraishi, Hidekazu Miura, Tomoyuki Yambe, Yoshinori Mitamura

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

We have advocated an axial flow blood pump called "valvo pump" that is implanted at the aortic valve position, and we have developed axial flow blood pumps to realize the concept of the valvo pump. The latest model of the axial flow blood pump mainly consists of a stator, a directly driven impeller, and a hydrodynamic bearing. The axial flow blood pump has a diameter of 33mm and length of 74mm, and the length of anatomical occupation is 33mm. The axial flow blood pump is anastomosed to the aorta with polytetrafluoroethylene (PTFE) cuffs worn on the inflow and outflow ports. Dp-Q curves of the axial flow blood pump are flatter than those of ordinary axial flow pumps, and pump outflow of 5L/min was obtained against a pressure difference of 50mmHg at a rotational speed of 9000rpm in vitro. The axial flow blood pump was installed in a goat by anastomosing with the thoracic descending aorta using PTFE cuffs, and it was rotated at a rotational speed of 8000rpm. Unlike in case of the ventricular assistance in parallel with the natural heart, pulsatilities of aortic pressure and aortic flow were preserved even when the pump was on, and mean aortic flow was increased by 1.5L/min with increase in mean aortic pressure of 30mmHg. In conclusion, circulatory assistance in series with the natural heart using the axial flow blood pump was able to improve hemodynamic pulsatility, and it would contribute to improvement of end-organ circulation.

Original languageEnglish
Pages (from-to)701-704
Number of pages4
JournalArtificial Organs
Volume39
Issue number8
DOIs
Publication statusPublished - 2015 Aug 1

Keywords

  • Artificial heart
  • Axial flow pump
  • Pulsatility
  • Ventricular assist device

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering

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