Inhibitory MHC class I receptors on myeloid cells

Akira Nakamura, Toshiyuki Takai

Research output: Contribution to journalReview articlepeer-review

Abstract

Inhibitory MHC class I receptors are mainly expressed on NK cells. NK cells bear various kinds of inhibitory MHC class I receptors, Killer cell immunoglobulin (Ig)-like receptors, CD94/NKG2A hetrodimer, and murine Ly49 receptor family for monitoring the expression of MHC class I on surrounding cells. Leukocyte Ig-like receptors (LILRs), which bind MHC class I molecules, are expressed on other immune cells, such as B cells, macrophages, dendritic cells (DCs) and mast cells. A murine LILR relative, paired Ig-like receptor (PIR), which is expressed on B cells and myeloid cells but not on NK and T cells, also recognizes MHC class I molecules as its ligand. Recent studies have revealed that some of these inhibitory receptors associate with MHC class I on the same cell surface (in cis). Moreover, the cis-interaction has been verified to regulate effector functions of NK cells or myeloid cells. In this review, we summarize recent discoveries on the functions of inhibitory MHC class I receptors, and discuss their regulatory roles in immune responses.

Original languageEnglish
Pages (from-to)80-87
Number of pages8
JournalCurrent Immunology Reviews
Volume4
Issue number2
DOIs
Publication statusPublished - 2008 May 1

Keywords

  • LILRB1
  • LILRB2
  • MHC class I
  • PIR-B

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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