Inhibitory histamine H3-receptors on cholinergic nerves in human airways

Masakazu Ichinose, Peter J. Barnes

Research output: Contribution to journalArticlepeer-review

103 Citations (Scopus)

Abstract

The histamine H3-agonist, (R)-α-methylhistamine (α-MeHA) caused a dose-dependent inhibition of cholinergic contractile responses to electrical field stimulation in human bronchi without affecting the basal tone. α-MeHA, but, did not alter the response to acetylcholine. Blockade of H1- and H2-receptors, or α- and β-adrenoceptors failed to prevent the inhibitory effect of α-MeHA, whereas the specific H3-antagonist, thioperamide, was effective. Our results indicate that H3-receptors modulate cholinergic neurotransmission in human airways.

Original languageEnglish
Pages (from-to)383-386
Number of pages4
JournalEuropean Journal of Pharmacology
Volume163
Issue number2-3
DOIs
Publication statusPublished - 1989 Apr 25
Externally publishedYes

Keywords

  • (Human)
  • (R)-α-Methylhistamine
  • Bronchi
  • Electrical field stimulation
  • Histamine H-receptor agonists

ASJC Scopus subject areas

  • Pharmacology

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