Abstract
The histamine H3-agonist, (R)-α-methylhistamine (α-MeHA) caused a dose-dependent inhibition of cholinergic contractile responses to electrical field stimulation in human bronchi without affecting the basal tone. α-MeHA, but, did not alter the response to acetylcholine. Blockade of H1- and H2-receptors, or α- and β-adrenoceptors failed to prevent the inhibitory effect of α-MeHA, whereas the specific H3-antagonist, thioperamide, was effective. Our results indicate that H3-receptors modulate cholinergic neurotransmission in human airways.
Original language | English |
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Pages (from-to) | 383-386 |
Number of pages | 4 |
Journal | European Journal of Pharmacology |
Volume | 163 |
Issue number | 2-3 |
DOIs | |
Publication status | Published - 1989 Apr 25 |
Externally published | Yes |
Keywords
- (Human)
- (R)-α-Methylhistamine
- Bronchi
- Electrical field stimulation
- Histamine H-receptor agonists
ASJC Scopus subject areas
- Pharmacology