Inhibitory effect of succinic acid on epithelial cell proliferation of colonic mucosa in rats

Akiko Inagaki, Hirofumi Ichikawa, Takashi Sakata

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Microbial breakdown of carbohydrates in the large intestine mainly produces short-chain fatty acids (SCFA). SCEA stimulate epithelial cell proliferation of the digestive tract in vivo. Succinic acid sometimes accumulates in the colonic lumen. However, the effect of succinic acid on colonic epithelial cell proliferation is unknown. Thus, we planned to clarify the influence of succinic acid on colonic epithelial cell proliferation in vivo. We continuously administered Infusate with or without succinic acid (100 mM) into the distal colon of rats for 6 d and measured accumulated mitosis per crypt of distal colon of these rats. Succinic acid infused into rat colons significantly inhibited colonic cell proliferation and reduced crypt size. These results clearly indicated the inhibitory effects of succinic acid on colonic epithelial cell proliferation in vivo.

Original languageEnglish
Pages (from-to)377-379
Number of pages3
JournalJournal of nutritional science and vitaminology
Volume53
Issue number4
DOIs
Publication statusPublished - 2007 Aug
Externally publishedYes

Keywords

  • Cell division
  • Large intestine
  • Short-chain fatty acids
  • Succinic acid

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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