Abstract
Microbial breakdown of carbohydrates in the large intestine mainly produces short-chain fatty acids (SCFA). SCEA stimulate epithelial cell proliferation of the digestive tract in vivo. Succinic acid sometimes accumulates in the colonic lumen. However, the effect of succinic acid on colonic epithelial cell proliferation is unknown. Thus, we planned to clarify the influence of succinic acid on colonic epithelial cell proliferation in vivo. We continuously administered Infusate with or without succinic acid (100 mM) into the distal colon of rats for 6 d and measured accumulated mitosis per crypt of distal colon of these rats. Succinic acid infused into rat colons significantly inhibited colonic cell proliferation and reduced crypt size. These results clearly indicated the inhibitory effects of succinic acid on colonic epithelial cell proliferation in vivo.
| Original language | English |
|---|---|
| Pages (from-to) | 377-379 |
| Number of pages | 3 |
| Journal | Journal of nutritional science and vitaminology |
| Volume | 53 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2007 Aug |
| Externally published | Yes |
Keywords
- Cell division
- Large intestine
- Short-chain fatty acids
- Succinic acid
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics