Inhibitory effect of Sphagnum palustre extract and its bioactive compounds on aromatase activity

Hee Jeong Eom, Yong Joo Park, Hee Rae Kang, Ha Ryong Kim, In Jae Bang, Hyun Bong Park, Kyu Hyuck Chung, Ki Hyun Kim

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Sphagnum palustre (a moss) has been traditionally used in Korea for the cure of several diseases such as cardiac pain and stroke. In this research, the inhibitory effect of S. palustre on aromatase (cytochrome P450 19, CYP19) activity was studied. [1ǃ-3H] androstenedione was used as a substrate and incubated with S. palustre extract and recombinant human CYP19 in the presence of NADPH. S. palustre extract inhibited aromatase in a concentration-dependent manner (IC50 value: 36.4 ± 8.1 µg/mL). To elucidate the major compounds responsible for the aromatase inhibitory effects of S. palustre extract, nine compounds were isolated from the extract and tested for their inhibition of aromatase activity. Compounds 1, 6, and 7 displayed aromatase inhibition, while the inhibition by the other compounds was negligible.

Original languageEnglish
Pages (from-to)661-665
Number of pages5
JournalBangladesh Journal of Pharmacology
Volume11
Issue number3
DOIs
Publication statusPublished - 2016 Jan 1

Keywords

  • Aromatase activity
  • Moss
  • Sphagnum palustre

ASJC Scopus subject areas

  • Pharmacology

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    Eom, H. J., Park, Y. J., Kang, H. R., Kim, H. R., Bang, I. J., Park, H. B., Chung, K. H., & Kim, K. H. (2016). Inhibitory effect of Sphagnum palustre extract and its bioactive compounds on aromatase activity. Bangladesh Journal of Pharmacology, 11(3), 661-665. https://doi.org/10.3329/bjp.v11i3.26776