Inhibitory effect of quinaldic acid on glucose-induced insulin release from isolated Langerhans islets of the rat

Hiroshi Okamoto, Susumu Miyamoto, Hiroshi Mabuchi, Ryoyu Takeda

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Influence of quinaldic acid on glucose-induced insulin release from isolated Langerhans islets of rats was studied. Glucose, in high concentration (15 mM), stimulated insulin release for 30 min after incubation (the first phase), followed by distinctly increasing release during the subsequent 60 min (the second phase). Addition of 12 mM quinaldic acid to an incubation medium containing 15 mM glucose caused almost complete inhibition in the second phase of glucose-induced insulin release, while the first phase was insensitive to quinaldic acid. A possible mechanism concerning the effect of quinaldic acid on β-cells of Langerhans islets is discussed.

Original languageEnglish
Pages (from-to)623-629
Number of pages7
JournalBiochemical and biophysical research communications
Volume59
Issue number2
DOIs
Publication statusPublished - 1974 Jul 24
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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