Inhibitory Effect of NND-318 on Ergosterol Synthesis in Trichophyton mentagrophytes and Candida albicans

Tetsuto Ohmi, Sadayoshi Sakumoto, Yoshimi Niwano, Hideki Oka, Takashi Suzuki, Matazaemon Uchida

Research output: Contribution to journalArticlepeer-review

Abstract

To clarify the mode of antifungal action of NND-318, a new imidazole antirriycotic, the effect of the agent on ergosterol synthesis in Trichophyton mentagrophytes and Candida albicans was examined, and compared to that of bifonazole. NND-318 was found to interfere with ergosterol biosynthesis by inhibition of sterol C-14 demethylation. In terms of drug concentrations exerting 50% inhibition of ergosterol biosynthesis, NND-318 was ≥25 times stronger than bifonazole.

Original languageEnglish
Pages (from-to)349-354
Number of pages6
JournalNippon Ishinkin Gakkai Zasshi
Volume33
Issue number3
DOIs
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Microbiology
  • Infectious Diseases

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