To clarify the mode of antifungal action of NND-318, a new imidazole antirriycotic, the effect of the agent on ergosterol synthesis in Trichophyton mentagrophytes and Candida albicans was examined, and compared to that of bifonazole. NND-318 was found to interfere with ergosterol biosynthesis by inhibition of sterol C-14 demethylation. In terms of drug concentrations exerting 50% inhibition of ergosterol biosynthesis, NND-318 was ≥25 times stronger than bifonazole.
ASJC Scopus subject areas
- Infectious Diseases