Inhibitory effect of neutralization of macrophage colony-stimulating factor in mechanical loading-induced osteoclastogenesis and odontoclastogenesis

Hideki Kitaura, Keisuke Kimura, Masahiko Ishida, Zaki Hakami, Saeed Jafari, Haruki Sugisawa, Harika Kohara, Masako Yoshimatsu, Teruko Takano-Yamamoto T

Research output: Contribution to journalArticlepeer-review

Abstract

Orthodontic tooth movement is achieved by the process of repeated alveolar bone resorption by osteoclasts. However, orthodontic force-induced root resorption by odontoclasts leads to serious problems. We established mechanical loading-induced tooth movement in a mouse model, in which a nickel-titanium coil spring was inserted between the upper incisors and the upper first molar. Macrophage colony-stimulating factor (M-CSF) is essential for osteoclastogenesis and odontoclastogenesis. We examined the effect of neutralization of M-CSF on mechanical loading-induced osteoclastogenesis and odontoclastogenesis in the mouse model. Mice were injected locally with M-CSF neutralization antibodies during mechanical loading-induced tooth movement. The number of osteoclasts and odontoclasts were counted in horizontal sections of the upper first molar after staining with tartrate-resistant acid phosphatase. The neutralization of M-CSF significantly inhibited osteoclastogenesis and odontoclastogenesis. These results suggested that the neutralization of M-CSF might be useful in controlling orthodontic tooth movement and root resorption.

Original languageEnglish
Pages (from-to)O-208-O-209
JournalTransactions of Japanese Society for Medical and Biological Engineering
Volume52
DOIs
Publication statusPublished - 2014 Aug 17

Keywords

  • M-CSF
  • Mechanical loading
  • Osteoclast

ASJC Scopus subject areas

  • Biomedical Engineering

Fingerprint Dive into the research topics of 'Inhibitory effect of neutralization of macrophage colony-stimulating factor in mechanical loading-induced osteoclastogenesis and odontoclastogenesis'. Together they form a unique fingerprint.

Cite this