Inhibitory effect of magnolol on tumour metastasis in mice

Koji Ikeda, Yoshimichi Sakai, Hisamitsu Nagase

Research output: Contribution to journalArticlepeer-review

74 Citations (Scopus)

Abstract

It has previously been reported that magnolol, a phenolic compound isolated from Magnolia obovata, inhibited tumour cell invasion in vitro. The purpose of this study was to investigate the antimetastatic effect of magnolol on tumour metastasis in vivo with experimental and spontaneous metastasis models and to clarify the mechanism. The antimetastatic effects of magnolol were evaluated by an experimental liver and spleen metastasis model using L5178Y-ML25 lymphoma, or an experimental and spontaneous lung metastasis model using B16-BL6 melanoma. Intraperitoneal (i.p.) administration of 2 or 10 mg/kg of magnolol significantly suppressed liver and spleen metastasis or lung metastasis. As for the spontaneous lung metastasis model using B16-BL6 melanoma, multiple i.p. administrations of 10 mg/kg of magnolol after and before tumour inoculation significantly suppressed lung metastasis and primary tumour growth. In addition, magnolol significantly inhibited B16-BL6 cell invasion of the reconstituted basement membrane (Matrigel, MG) without affecting cell growth. These data from the in vivo experiments suggest that magnolol possesses strong antimetastatic ability and that it may be a lead compound for drug development. The antimetastatic action of magnolol is considered to be due to its ability to inhibit tumour cell invasion.

Original languageEnglish
Pages (from-to)933-937
Number of pages5
JournalPhytotherapy Research
Volume17
Issue number8
DOIs
Publication statusPublished - 2003 Sep 1
Externally publishedYes

Keywords

  • Invasion
  • Magnolia obovata
  • Magnolol
  • Metastasis
  • Mice
  • Natural products

ASJC Scopus subject areas

  • Pharmacology

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