Inhibitory effect of magnolol and honokiol from Magnolia obovata on human fibrosarcoma HT-1080 invasiveness in vitro

H. Nagase, K. Ikeda, Y. Sakai

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)

Abstract

We investigated the inhibitory effect of Magnolia obovata Thunb. bark ethanol extracts on human fibrosarcoma HT-1080 cells invasion in a reconstituted basement membrane [Matrigel (MG)]. We found that the effective components of the bark ethanol extracts were magnolol and honokiol, two biphenyl compounds. The extracts, magnolol and honokiol, did not affect HT-1080 cells adhesion to MG, but did inhibit HT-1080 cells migration at a high concentration (100 μM). HT-1080 cells secrete matrix metalloproteinase (MMP)-9, which degrades the extracellular matrix as a part of the invasive process. Magnolol and honokiol inhibited the activity of MMP-9, which may have been responsible, in part, for the inhibition of tumor cell invasiveness.

Original languageEnglish
Pages (from-to)705-708
Number of pages4
JournalPlanta Medica
Volume67
Issue number8
DOIs
Publication statusPublished - 2001
Externally publishedYes

Keywords

  • Honokiol
  • Magnolia obovata
  • Magnoliacea
  • Magnolol
  • Matrix metalloproteinases
  • Tumor cell invasion

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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