Inhibitory effect of interferon-γ on experimental tooth movement in mice

Haruka Kohara, Hideki Kitaura, Masako Yoshimatsu, Yuji Fujimura, Yukiko Morita, Toshiko Eguchi, Noriaki Yoshida

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The aim of this study was to investigate the effects of interferon (IFN)-γ on experimental tooth movement in mice using a murine experimental tooth movement model. An Ni-Ti closed-coil spring was inserted between the upper-anterior alveolar bones and the upper-left first molars in mice. We evaluated the relationship between local Ifn-γ mRNA levels and orthodontic tooth movement. In other experiments, IFN-γ was injected adjacent to each first molar every other day during tooth movement. After 12 days, the amount of tooth movement was measured. Tartrate-resistant acid phosphatase (TRAP)-positive cells at the pressure side of each experimental tooth were counted as osteoclasts. Local Ifn-γ mRNA expression increased with orthodontic tooth movement. The number of TRAP-positive cells increased on the pressure side of the first molar. In contrast, the degree of tooth movement and the number of TRAP-positive cells on the pressure side in IFN-γ-injected mice were less than those of control mice. IFN-γ was induced in experimental tooth movement, and could inhibit mechanical force-loaded osteoclastogenesis and tooth movement. These results suggest that IFN-γ might be useful in controlling orthodontic tooth movement because of its inhibitory action on excessive osteoclastogenesis during this movement.

Original languageEnglish
Pages (from-to)426-431
Number of pages6
JournalJournal of Interferon and Cytokine Research
Volume32
Issue number9
DOIs
Publication statusPublished - 2012 Sep 1

ASJC Scopus subject areas

  • Immunology
  • Cell Biology
  • Virology

Fingerprint Dive into the research topics of 'Inhibitory effect of interferon-γ on experimental tooth movement in mice'. Together they form a unique fingerprint.

Cite this